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מיטאקי - Grifola frondosa

עודכן בתאריך 07/04/2022

Maitake


משפחה בוטנית: Meripilaceae

חלק הצמח | איכויות | רכיבים פעילים | התוויות | מינונים | רגישות | תופעות לוואי | 

מינון יתר | אזהרות | התוויות נגד | רעילות | אינטראקציות | הריון | הנקה

 

משמעות השם מיטאקי ביפנית הינו "פטריה מרקדת".

מיטאקי הינה פטריית מאכל רב-שנתית, אך בבגרותה בשרה הופך קשיח מדי לאכילה.

מוצאה בצפון-מזרח יפן וצפון אמריקה.

מיטאקי מוכרת ע"י משרד הבריאות הישראלי כפטריית מרפא - ניתן לראות את הרשימה המלאה כאן.

 

חלק הצמח בשימוש

גוף הפטריה.

 

איכויות

טמפרטורה: ניטראלית.

לחות: ניטראלית.

טעם: מעט מתקתק, מעט מצמת.

 

רכיבים פעילים עיקריים

פוליסכרידים (b-glucans), סטרולים, חומצות אורגניות (octadecanoic acid, octadecadienoic acid), פוספוליפידים (phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol, phosphatidylserine, phosphatidic acid).

 

התוויות

סרטן, סוכרת, עודף שומנים בדם, לחץ דם גבוה, דלקות כבד, תמיכה בירידה במשקל.

 

מינונים

תמצית נוזלית בריכוז 1:3, 45% אלכוהול – 5-15 מ"ל ביום.

תמצית יבשה מתוקננת בריכוז 30% פוליסכרידים – 200-600 מ"ג ביום.

מרתח – 3-9 גרם ביום.

בפורמולה – 20%-30%.

 

רגישות

קיים דיווח בודד אודות     למידע השלם למנויים

 

תופעות לוואי

אאוזנופיליה חסרת תסמינים נצפתה בקרב ארבעה מטופלים במחקר     למידע השלם למנויים

 

מינון יתר
לא ידוע על תופעות הנגרמות ממינון יתר של פטריית מיטאקי.

 

אזהרות וצעדי מנע
לא ידוע על אזהרות או צעדי מנע שיש לנקוט.

 

התוויות נגד
לא ידועות התוויות נגד.

 

רעילות 

במחקר קליני שנערך על חולות סרטן שד וכלל שימוש בתמצית פוליסכרידים ממיטאקי    למידע השלם למנויים

 

תגובות הדדיות עם תרופות / צמחי מרפא / תוספי תזונה 

 

תרופות להורדת סוכר -    למידע השלם למנויים

 

תרופה להשריית ביוץ (Clomiphene citrate) -    למידע השלם למנויים

 

תרופות להפחתת לחץ-דם -    למידע השלם למנויים

 

תרופות מדכאות חיסון -    למידע השלם למנויים

 

תרופות נוגדות קרישה (Warfarin) -    למידע השלם למנויים

 

אינטרפרון (Interferon) -    למידע השלם למנויים

 

תרופות להורדת רמות שומנים -    למידע השלם למנויים

 

התרופה Mitomycin C -    למידע השלם למנויים


התרופה Carmustine -    למידע השלם למנויים


התרופה Cyclophosphamide -    למידע השלם למנויים


התרופה 5-FU -    למידע השלם למנויים

 

התרופה Cisplatin -    למידע השלם למנויים


התרופה Paclitaxel -    למידע השלם למנויים


התרופה Doxorubicin -    למידע השלם למנויים


התרופה Etoposide -    למידע השלם למנויים

 

ויטמין C -    למידע השלם למנויים


ויטמין K -    למידע השלם למנויים

 

 

הריון -    למידע השלם למנויים

 

הנקה -    למידע השלם למנויים

 

 

מקורות

  1. Tanaka H, Tsunematsu K, Nakamura N, et al. Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol. Intern.Med. 2004;43(8):737-740. https://www.ncbi.nlm.nih.gov/pubmed/15468977
  2. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. 2014. https://www.ncbi.nlm.nih.gov/pubmed/25351719
  3. Deng G, Lin H, Seidman A, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J.Cancer Res.Clin.Oncol. 2009;135(9):1215-1221. https://www.ncbi.nlm.nih.gov/pubmed/19253021
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J. Altern. Compl. Med., 16(12):1-5, 2010. https://www.ncbi.nlm.nih.gov/pubmed/21034160
  5. Gonmori K, Yokoyama K. [Acute encephalopathy caused by cyanogenic fungi in 2004, and magic mushroom regulation in Japan]. Chudoku.Kenkyu 2009;22(1):61-69. https://www.ncbi.nlm.nih.gov/pubmed/19344063
  6. Konno S. A mushroom extract for Syndrome X and type II diabetes. Natural Pharmacy. 2003;7(5):16-17.
  7. Nanba H, Kubo K. Effect of Maitake D-fraction on cancer prevention. Ann N Y Acad Sci. 1997 Dec 29;833:204-7. https://pubmed.ncbi.nlm.nih.gov/9616756/
  8. Finkelstein MP, Aynehchi S, Samadi AA, et al. Chemosensitization of carmustine with maitake beta-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I. J. Altern. Compl. Med., 8(5):573-580, 2002. https://www.ncbi.nlm.nih.gov/pubmed/12470438
  9. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1989;35(1):91-94. https://www.ncbi.nlm.nih.gov/pubmed/2738717
  10. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol.(Tokyo) 1987;33(5):341-346. https://www.ncbi.nlm.nih.gov/pubmed/3443885.
  11. Inoue A, Kodama N, Nanba H. Effect of maitake (grifolafrondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull 2002;25(4):536-540. https://www.ncbi.nlm.nih.gov/pubmed/11995941
  12. Ohno N, Egawa Y, Hashimoto T, et al. Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice. Biol Pharm Bull 1996;19(4):608-612. https://www.ncbi.nlm.nih.gov/pubmed/8860968
  13. Wu MJ, Cheng TL, Cheng SY, et al. Immunomodulatory properties of Grifola frondosa in submerged culture. J Agric.FoodChem 4-19-2006;54(8):2906-2914. https://www.ncbi.nlm.nih.gov/pubmed/16608207
  14. Yang BK, Gu YA, Jeong YT, et al. Chemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process. Int J Biol Macromol. 8-1-2007;41(3):227-233. https://www.ncbi.nlm.nih.gov/pubmed/17418400
  15. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother. 2010 Jan;44(1):223-4. Epub 2009 Dec 29. https://www.ncbi.nlm.nih.gov/pubmed/20040699
  16. Gu CQ, Li J, Chao FH. Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15. Antiviral Res 2006;72(2):162-165. https://www.ncbi.nlm.nih.gov/pubmed/16846649
  17. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med. 2001 Dec;18(12):1010.  https://pubmed.ncbi.nlm.nih.gov/11903406/
  18. Dilani D. De Silva DD, Rapior S, Hyde KD, Bahkali AH. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Diversity (2012) 56:1–29. https://www.researchgate.net/publication/234166650
  19. Ulbricht C, Weissner W, Basch E, et al. Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration. J Soc Integr Oncol. 2009 Spring;7(2):66-72. https://pubmed.ncbi.nlm.nih.gov/19476741/
  20. Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull. 1994 Aug;17(8):1106-10. https://pubmed.ncbi.nlm.nih.gov/7820117/
  21. Manohar V, Talpur NA, Echard BW, et al. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes Metab 2002;4:43-8. https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1046/j.1463-1326.2002.00180.x
  22. Horio H, Ohtsuru M. Maitake (Grifóla frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sei Vitaminol (Tokyo) 2001;47:57-63. https://pubmed.ncbi.nlm.nih.gov/11349892/
  23. Hong L, Xun M, Wutong W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. J Pharm Pharmacol. 2007 Apr;59(4):575-82. https://pubmed.ncbi.nlm.nih.gov/17430642/
  24. Louie B, Rajamahanty S, Won J, et al. Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells. BJU Int. 2010 Apr;105(7):1011-5. https://pubmed.ncbi.nlm.nih.gov/19735256/
  25. Tan CSS, Lee SWH. Warfarin and food, herbal or dietary supplement interactions: A systematic review. Br J Clin Pharmacol. 2020 Jun 1. https://pubmed.ncbi.nlm.nih.gov/32478963/
  26. Pyo P, Louie B, Rajamahanty S, et al. Possible immunotherapeutic potentiation with D-fraction in prostate cancer cells. J Hematol Oncol. 2008 Dec 4;1:25. https://pubmed.ncbi.nlm.nih.gov/19055833/
  27. Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev. 2006 Jun;11(2):128-50. https://pubmed.ncbi.nlm.nih.gov/16813462/
  28. Preuss HG, Echard B, Bagchi D, Perricone NV. Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats. Int J Med Sci. 2010 Jun 7;7(4):169-80. https://pubmed.ncbi.nlm.nih.gov/20567593/
  29. Nanba H. Maitake D-fraction: healing and preventing potentials for cancer. Townsend Lett Doctors Patients 1996;151/152:84-5. https://isom.ca/wp-content/uploads/2020/01/JOM_1997_12_1_07_Maitake_D-fraction_Healing_and_Preventive_Potential_for-.pdf
  30. Kodama N, Murata Y, Asakawa A, et al. Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice. Nutrition. 2005 May;21(5):624-9. https://pubmed.ncbi.nlm.nih.gov/15850970/
  31. Mao GH, Zhang ZH, Fei F, et al. Effect of Grifola frondosa polysaccharide on anti-tumor activity in combination with 5-Fu in Heps-bearing mice. Int J Biol Macromol. 2019. Jan;121:930-935. https://pubmed.ncbi.nlm.nih.gov/30342137/
  32. Mao G, Li Q, Deng C, et al. The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice. Int J Biol Macromol. 2018 Feb;107(Pt B):2211-2216. https://pubmed.ncbi.nlm.nih.gov/29042284/
  33. Masuda Y, Inoue M, Miyata A, et al. Maitake beta-glucan enhances therapeutic effect and reduces myelosuppression and nephrotoxicity of cisplatin in mice. Int Immunopharmacol. 2009 May;9(5):620-6. https://pubmed.ncbi.nlm.nih.gov/19249389/
  34. Lin H, de Stanchina E, Zhou XK, et al. Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity. Cancer Immunol Immunother. 2010 Jun;59(6):885-97. https://pubmed.ncbi.nlm.nih.gov/20140432/
  35. Meng M, Guo M, Feng C, et al. Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways. Food Funct. 2019 Aug 1;10(8):4998-5007.  https://pubmed.ncbi.nlm.nih.gov/31355400/
  36. Li Q, Chen G, Chen H, et al. Se-enriched G. frondosa polysaccharide protects against immunosuppression in cyclophosphamide-induced mice via MAPKs signal transduction pathway. Carbohydr Polym. 2018 Sep 15;196:445-456.  https://pubmed.ncbi.nlm.nih.gov/29891317/
  37. Lin H, She YH, Cassileth BR, et al. Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro. Int Immunopharmacol. 2004 Jan;4(1):91-9. https://pubmed.ncbi.nlm.nih.gov/14975363/
  38. Lin H, Cheung SW, Nesin M, et al. Enhancement of umbilical cord blood cell hematopoiesis by maitake beta-glucan is mediated by granulocyte colony-stimulating factor production. Clin Vaccine Immunol 2007;14:21-7. https://pubmed.ncbi.nlm.nih.gov/17093103/
  39. Zhao F, Wang YF, Song L, et al. Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells. Integr Cancer Ther. 2017 Jun;16(2):205-214. https://pubmed.ncbi.nlm.nih.gov/27151580/
  40. Duan L, Wu XL, Zhao F, et al. Induction Effect to Apoptosis by Maitake Polysaccharide: Synergistic Effect of Its Combination with Vitamin C in Neuroglioma Cell. J Evid Based Complementary Altern Med. 2017 Oct;22(4):667-674. https://pubmed.ncbi.nlm.nih.gov/28528571
  41. Alexander B, Fishman AI, Eshghi M, et al. Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C. Integr Cancer Ther. 2013 Sep;12(5):442-8. https://pubmed.ncbi.nlm.nih.gov/23341484/
  42. Sato M, Tokuji Y, Yoneyama S, et al. Effect of dietary Maitake (Grifola frondosa) mushrooms on plasma cholesterol and hepatic gene expression in cholesterol-fed mice. J Oleo Sci. 2013;62(12):1049-58. https://pubmed.ncbi.nlm.nih.gov/24292357/
  43. Ding Y, Xiao C, Wu Q, et al. The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats. Front Microbiol. 2016 Aug 3;7:1186. https://pubmed.ncbi.nlm.nih.gov/27536279/
  44. Guo WL, Deng JC, Pan YY, et al. Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin. Int J Biol Macromol. 2020 Jun 15;153:1231-1240. https://pubmed.ncbi.nlm.nih.gov/31759027/
  45. Fukushima M, Ohashi T, Fujiwara Y, et al. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood). 2001 Sep;226(8):758-65. https://pubmed.ncbi.nlm.nih.gov/11520942/
  46. Pan YY, Zeng F, Guo WL, et al. Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats. Food Funct. 2018 Dec 13;9(12):6268-6278. https://pubmed.ncbi.nlm.nih.gov/30403219/
  47. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull. 1997 Jul;20(7):781-5. https://pubmed.ncbi.nlm.nih.gov/9255420/
  48. Shen KP, Su CH, Lu TM, et al. Effects of Grifola frondosa non-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice. Pharm Biol. 2015 May;53(5):705-9. https://pubmed.ncbi.nlm.nih.gov/25431253/
  49. Lei H, Guo S, Han J, et al. Hypoglycemic and hypolipidemic activities of MT-α-glucan and its effect on immune function of diabetic mice. Carbohydr Polym. 2012 Jun 5;89(1):245-50. https://pubmed.ncbi.nlm.nih.gov/24750630/
  50. Lo HC, Hsu TH, Chen CY. Submerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats. Am J Chin Med. 2008;36(2):265-85. https://pubmed.ncbi.nlm.nih.gov/18457360/
  51. Cui B, Han L, Qu J, Lv Y. Hypoglycemic activity of Grifola frondosa rich in vanadium. Biol Trace Elem Res. 2009 Nov;131(2):186-91. https://pubmed.ncbi.nlm.nih.gov/19283341/
  52. Ma X, Zhou F, Chen Y, Zhang Y, Hou L, Cao X, Wang C. A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway. Glycoconj J. 2014 Jul;31(5):355-63. https://pubmed.ncbi.nlm.nih.gov/24908430/
  53. Preuss HG, Echard B, Bagchi D, et al. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol Cell Biochem. 2007 Dec;306(1-2):105-13. https://pubmed.ncbi.nlm.nih.gov/17671829/
  54. Rajamahanty S, Louie B, O'Neill C, Choudhury M, Konno S. Possible disease remission in patient with invasive bladder cancer with D-fraction regimen. Int J Gen Med. 2009 Jul 30;2:15-7. https://pubmed.ncbi.nlm.nih.gov/20360882/
  55. Konno S. Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy. Int J Gen Med. 2009 Jul 30;2:91-108. https://pubmed.ncbi.nlm.nih.gov/20360893/
  56. Konno S. Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts. Altern Med Rev. 2007 Mar;12(1):63-8.  https://pubmed.ncbi.nlm.nih.gov/17397268/
  57. Konno S, Aynehchi S, Dolin DJ, et al. Anticancer and hypoglycemic effects of polysaccharides in edible and medicinal maitake mushroom S F Gray. International Journal of Medicinal Mushrooms, 2002, 4(3): 185-195. https://eurekamag.com/research/034/418/034418996.php
  58. Konno S, Alexander B, Zade J, Choudhury M. Possible hypoglycemic action of SX-fraction targeting insulin signal transduction pathway. Int J Gen Med. 2013;6:181-7. https://pubmed.ncbi.nlm.nih.gov/23569395/
  59. Degen M, Alexander B, Choudhury M, et al. Alternative therapeutic approach to renal-cell carcinoma: induction of apoptosis with combination of vitamin K3 and D-fraction. J Endourol. 2013 Dec;27(12):1499-503.  https://pubmed.ncbi.nlm.nih.gov/24341344/
  60. Xiao C, Wu Q, Xie Y, et al. Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats. Food Funct. 2015 Nov;6(11):3567-75. https://pubmed.ncbi.nlm.nih.gov/26311233/
  61. Aoki H, Hanayama M, Mori K, Sato R. Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice. Biosci Biotechnol Biochem. 2018 Sep;82(9):1550-1559. https://pubmed.ncbi.nlm.nih.gov/29873587/
  62. Xu Q, Guo J. Activity and toxicity of Cr(III)-enriched Grifola frondosa in insulin-resistant mice. Biol Trace Elem Res. 2009 Dec;131(3):271-7. https://pubmed.ncbi.nlm.nih.gov/19319487/
  63. Hong L, Qin W, Shuzhen G, et al. The protective effect of MT-α-glucan against streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage. Carbohydr Polym. 2013 Feb 15;92(2):1211-7. doi: 10.1016/j.carbpol.2012.10.037. https://pubmed.ncbi.nlm.nih.gov/23399148/
  64. Talpur NA, Echard BW, Fan AY, et al. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol Cell Biochem. 2002 Aug;237(1-2):129-36. https://pubmed.ncbi.nlm.nih.gov/12236580/
  65. Preuss HG, Echard B, Fu J, et al. Fraction SX of maitake mushroom favorably influences blood glucose levels and blood pressure in streptozotocin-induced diabetic rats. J Med Food. 2012 Oct;15(10):901-8. https://pubmed.ncbi.nlm.nih.gov/22873755/
  66. Chen Y, Liu D, Wang D, et al. Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice. Food Chem Toxicol. 2019 Apr;126:295-302. https://pubmed.ncbi.nlm.nih.gov/30826407/
  67. Talpur N, Echard B, Dadgar A, et al. Effects of Maitake mushroom fractions on blood pressure of Zucker fatty rats. Res Commun Mol Pathol Pharmacol. 2002;112(1-4):68-82. https://pubmed.ncbi.nlm.nih.gov/15080498/
  68. Manohar V, Talpur NA, Echard BW, et al. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes Metab 2002;4:43-8. https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1046/j.1463-1326.
  69. Chen Y, Liu Y, Sarker MMR, Yan X, et al. Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways. Carbohydr Polym. 2018 Oct 15;198:452-461. https://pubmed.ncbi.nlm.nih.gov/30093022/
  70. Lei H, Zhang M, Wang Q, et al. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-81. https://pubmed.ncbi.nlm.nih.gov/23796219/

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